Unhandled exception: 400: Site connection not initiated ([Errno 11] Resource temporarily unavailable)

CMK version: 2.2.0p45
OS version: Centos 7

Error message:
Unhandled exception: 400: Site connection not initiated ([Errno 11] Resource temporarily unavailable).

Message from liveproxyd.log:
2025-09-09 11:51:08,858 [40] [cmk.liveproxyd.(179399).Site(atl).Thread(Thread-3517).Channel(None)] Failed to create channel to /omd/sites/atl/tmp/run/live: [Errno 11] Resource temporarily unavailable

Description
Cannot activate changes on this server via GUI after migrating from 2.1 to 2.2 cmk. Seem to have an issue attempting to access the socket “/omd/sites/atl/tmp/run/live=”

no errors in cmc.log indicating issue with socket outside of generic issue. OMD status appears healthy:

agent-receiver: running
mkeventd: running
liveproxyd: running
mknotifyd: running
rrdcached: running
cmc: running
apache: running
dcd: running
redis: running
stunnel: running
xinetd: running
crontab: running

Overall state: running

Wondering if there is something overloading the socket, or preventing the socket from initializing correctly? Tried to manually connect to socket, but times out. Anyone else experience this before?